Product Policy, Biosecurity Policy Manager

About the Team

The Product Policy team develops, implements, enforces, and communicates the policies that govern use of OpenAI’s services, including ChatGPT, Codex, GPTs, and the OpenAI API. This biosecurity-focused role will help define how OpenAI enables legitimate life sciences, biomedical, and public health work while reducing the risk that our products are misused to create biological harm.

This role sits at the intersection of AI capability, life sciences practice, biosecurity, biosafety, and abuse prevention: helping researchers, institutions, and other legitimate users benefit from OpenAI’s tools while setting clear boundaries against activity that could enable catastrophic biological misuse or other harmful bio-related outcomes.

About the Role

As a Product Policy Manager specializing in Biosecurity, you will combine deep biological, biosecurity, and policy judgment to guide how OpenAI evaluates, launches, and governs capabilities relevant to biology and the life sciences. You will work closely with product, engineering, research, safety, security, legal, operations, global affairs, and go-to-market teams to translate complex biological risk into practical product policy, implementation standards, access criteria, enforcement guidance, and launch decisions.

The role requires understanding both sides of the bio equation: how legitimate researchers, clinicians, public health practitioners, and life sciences organizations use AI to advance beneficial work, and how malicious or irresponsible actors may attempt to misuse AI systems to lower barriers to harmful biological activity. Strong candidates may bring depth in one or more relevant domains, such as biosecurity, biosafety, synthetic biology, molecular biology, computational biology, bioinformatics, public health, biodefense, biological risk management, sequence screening, lab automation, institutional research governance, or life sciences R&D — along with the ability to reason across adjacent areas.

You do not need to have held a formal policy title, but you should have experience turning complex technical or scientific risk into durable rules, standards, processes, or decisions, and very strong communication skills.

As OpenAI continues to grow its capabilities in biology and the life sciences, this role will help align diverse teams and stakeholders while operating in a fast-moving, ambiguous environment.

In this role, you will

• Provide biosecurity and life sciences policy advice to technical and product teams based on an understanding of model capabilities, biological R&D workflows, abuse pathways, and the practical needs of legitimate scientific users.

• Evaluate bio-relevant product launches and model capabilities, including how they may support beneficial biological research, public health, clinical education, drug discovery, biosecurity, and other life sciences use cases, as well as how they could be misused by malicious or irresponsible actors.

• Translate biological misuse risk into clear product requirements, launch guidance, enforcement standards, user-facing policy, internal implementation guidance, and reviewer SOPs.

• Help define scalable policy frameworks for dual-use biological capabilities, including where to draw boundaries between broadly beneficial biological assistance, higher-risk dual-use support, and activity that should be restricted or disallowed.

• Develop operationalizable standards, enforcement protocols, and escalation paths for bio misuse scenarios, including suspicious high-risk dual-use trajectories, account- or organization-level misuse patterns, and ambiguous cases requiring expert judgment.

• Partner with Preparedness, Safety Systems, Integrity, User Operations, I2, research, legal, communications, global affairs, and product teams to make principled, timely decisions about biological risk in high-ambiguity situations.

• Help design and refine trusted access frameworks for higher-capability biological systems,